Circadian disruption, clock genes, and metabolic health
Society of Environmental Toxicology and Chemistry · University of Wisconsin–Madison · +5 more institutions
Abstract
A growing body of research has identified circadian-rhythm disruption as a risk factor for metabolic health. However, the underlying biological basis remains complex, and complete molecular mechanisms are unknown. There is emerging evidence from animal and human research to suggest that the expression of core circadian genes, such as circadian locomotor output cycles kaput gene (CLOCK), brain and muscle ARNT-Like 1 gene (BMAL1), period (PER), and cyptochrome (CRY), and the consequent expression of hundreds of circadian output genes are integral to the regulation of cellular metabolism. These circadian mechanisms represent potential pathophysiological pathways linking circadian disruption to adverse metabolic…
Citation impact
- FWCI
- 38.16
- Percentile
- 100%
- References
- 103
Authors
5- LALauren A. Schrader
Society of Environmental Toxicology and Chemistry
- SMSean M. Ronnekleiv‐Kelly
University of Wisconsin–Madison, Society of Environmental Toxicology and Chemistry, Wisconsin Division of Public Health
- JBJohn B. Hogenesch
Cincinnati Children's Hospital Medical Center
- CAChristopher A. Bradfield
Society of Environmental Toxicology and Chemistry
- KMKristen MaleckiCorresponding
University of Wisconsin–Madison, Chicago Department of Public Health, University of Illinois Chicago, University of Illinois Hospital & Health Sciences System, Society of Environmental Toxicology and Chemistry
Topics & keywords
- Circadian rhythm
- Biology
- Circadian clock
- CLOCK
- Neuroscience
- Bioinformatics
- Endocrinology