Mass spectrometry imaging for spatially resolved multi-omics molecular mapping

The recent upswing in the integration of spatial multi-omics for conducting multidimensional information measurements is opening a new chapter in biological research. Mapping the landscape of various biomolecules including metabolites, proteins, nucleic acids, etc., and even deciphering their functional interactions and pathways is believed to provide a more holistic and nuanced exploration of the molecular intricacies within living systems. Mass spectrometry imaging (MSI) stands as a forefront technique for spatially mapping the metabolome, lipidome, and proteome within diverse tissue and cell samples. In this review, we offer a systematic survey delineating different MSI techniques for spatially resolved…

• UD
  U.S. Department of Agriculture

  Award: 2018-67001-28266
• UO
  University of Wisconsin-Madison

  Award: P30 DK020579
• UO
  University of Wisconsin Carbone Cancer Center

  Award: 233-AAI9632
• NI
  National Institutes of Health

  Awards: P01CA250972, R01 AG078794, AG078794, R01 DK071801, R01AG052324, DK020579, DK071801, R01 DK071801, R01 AG078794, R01AG052324, P01CA250972, P30 DK020579