articleCellJul 22, 2024HYBRID OA

Innate immune memory after brain injury drives inflammatory cardiac dysfunction

ASAlba SimatsSZSijia ZhangDMDenise MessererFCFaye ChongSBSude Beşkardeş

Ludwig-Maximilians-Universität München · Consejo Superior de Investigaciones Científicas · +14 more institutions

PubMed
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Abstract

The medical burden of stroke extends beyond the brain injury itself and is largely determined by chronic comorbidities that develop secondarily. We hypothesized that these comorbidities might share a common immunological cause, yet chronic effects post-stroke on systemic immunity are underexplored. Here, we identify myeloid innate immune memory as a cause of remote organ dysfunction after stroke. Single-cell sequencing revealed persistent pro-inflammatory changes in monocytes/macrophages in multiple organs up to 3 months after brain injury, notably in the heart, leading to cardiac fibrosis and dysfunction in both mice and stroke patients. IL-1β was identified as a key driver of epigenetic changes in innate…

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115
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25.51
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100%
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95
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Authors

29

Topics & keywords

Topics
Keywords
  • Innate immune system
  • Stroke (engine)
  • Immunology
  • Inflammation
  • Immune system
  • Cardiac dysfunction
  • Biology
  • Immunotherapy
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