Endoplasmic reticulum stress—a key guardian in cancer
Central South University · Hunan Cancer Hospital · +3 more institutions
Abstract
Endoplasmic reticulum stress (ERS) is a cellular stress response characterized by excessive contraction of the endoplasmic reticulum (ER). It is a pathological hallmark of many diseases, such as diabetes, obesity, and neurodegenerative diseases. In the unique growth characteristic and varied microenvironment of cancer, high levels of stress are necessary to maintain the rapid proliferation and metastasis of tumor cells. This process is closely related to ERS, which enhances the ability of tumor cells to adapt to unfavorable environments and promotes the malignant progression of cancer. In this paper, we review the roles and mechanisms of ERS in tumor cell proliferation, apoptosis, metastasis, angiogenesis,…
Citation impact
- FWCI
- 41.08
- Percentile
- 100%
- References
- 179
Authors
20- WZWenlong ZhangCorresponding
Central South University, Hunan Cancer Hospital, University of South China
- YSYidan Shi
Hunan Normal University
- LOLinda Oyang
Central South University, Hunan Cancer Hospital
- SCShiwen Cui
Central South University, Hunan Cancer Hospital, University of South China
- SLShizhen Li
Central South University, Hunan Cancer Hospital, University of South China
Topics & keywords
- Endoplasmic reticulum
- Unfolded protein response
- ATF6
- Metastasis
- Angiogenesis
- Cancer
- Cancer research
- Cancer cell
- Good health and well-being