Oxidative cell death in cancer: mechanisms and therapeutic opportunities
Guiyang Medical University · Guangzhou Medical University · +4 more institutions
Abstract
Abstract Reactive oxygen species (ROS) are highly reactive oxygen-containing molecules generated as natural byproducts during cellular processes, including metabolism. Under normal conditions, ROS play crucial roles in diverse cellular functions, including cell signaling and immune responses. However, a disturbance in the balance between ROS production and cellular antioxidant defenses can lead to an excessive ROS buildup, causing oxidative stress. This stress damages essential cellular components, including lipids, proteins, and DNA, potentially culminating in oxidative cell death. This form of cell death can take various forms, such as ferroptosis, apoptosis, necroptosis, pyroptosis, paraptosis, parthanatos,…
Citation impact
- FWCI
- 154.22
- Percentile
- 100%
- References
- 288
Authors
6- XAXiaoqin An
Guiyang Medical University, Guangzhou Medical University
- WYWenfeng Yu
Guiyang Medical University
- JLJinbao Liu
State Key Laboratory of Respiratory Disease, Guangzhou Medical University
- DTDaolin TangCorresponding
Southwestern Medical Center, Southwestern Medical Center, The University of Texas Southwestern Medical Center
- YLYang Li
Guiyang Medical University
Topics & keywords
- Necroptosis
- Oxidative stress
- Pyroptosis
- Programmed cell death
- Reactive oxygen species
- Cell biology
- Carcinogenesis
- Cancer cell
- Good health and well-being