New insights into the role of mitochondrial dynamics in oxidative stress-induced diseases
Chinese Academy of Sciences · Institute of Subtropical Agriculture · +2 more institutions
Abstract
The accumulation of excess reactive oxygen species (ROS) can lead to oxidative stress (OS), which can induce gene mutations, protein denaturation, and lipid peroxidation directly or indirectly. The expression is reduced ATP level in cells, increased cytoplasmic Ca2+, inflammation, and so on. Consequently, ROS are recognized as significant risk factors for human aging and various diseases, including diabetes, cardiovascular diseases, and neurodegenerative diseases. Mitochondria are involved in the production of ROS through the respiratory chain. Abnormal mitochondrial characteristics, including mitochondrial OS, mitochondrial fission, mitochondrial fusion, and mitophagy, play an important role in various…
Citation impact
- FWCI
- 35.45
- Percentile
- 100%
- References
- 171
Authors
6- SCSisi Chen
Chinese Academy of Sciences, Institute of Subtropical Agriculture, University of Chinese Academy of Sciences
- QLQilong Li
Chinese Academy of Sciences, Institute of Subtropical Agriculture, University of Chinese Academy of Sciences
- HSHanjing Shi
Hunan Normal University, Chinese Academy of Sciences, Institute of Subtropical Agriculture
- FLFengna Li
Chinese Academy of Sciences, Institute of Subtropical Agriculture, University of Chinese Academy of Sciences
- YDYehui Duan
Chinese Academy of Sciences, Institute of Subtropical Agriculture, University of Chinese Academy of Sciences
Topics & keywords
- Oxidative stress
- Mitochondrion
- Dynamics (music)
- Oxidative damage
- Oxidative phosphorylation
- Cell biology
- Biology
- Physics
- Zero hunger