The Interplay between Extracellular Matrix Remodeling and Cancer Therapeutics
University of Twente · Technion – Israel Institute of Technology
Abstract
The extracellular matrix (ECM) is an abundant noncellular component of most solid tumors known to support tumor progression and metastasis. The interplay between the ECM and cancer therapeutics opens up new avenues in understanding cancer biology. While the ECM is known to protect the tumor from anticancer agents by serving as a biomechanical barrier, emerging studies show that various cancer therapies induce ECM remodeling, resulting in therapy resistance and tumor progression. This review discusses critical issues in this field including how the ECM influences treatment outcome, how cancer therapies affect ECM remodeling, and the challenges associated with targeting the ECM. Significance: The intricate…
Citation impact
- FWCI
- 69.57
- Percentile
- 100%
- References
- 111
Authors
2Topics & keywords
- Extracellular matrix
- Cancer
- Metastasis
- Tumor progression
- Cancer research
- Tumor microenvironment
- Medicine
- Biology
- Good health and well-being