Targeting Lactobacillus johnsonii to reverse chronic kidney disease
Zhejiang Chinese Medical University · Macau University of Science and Technology · +9 more institutions
Abstract
Accumulated evidence suggested that gut microbial dysbiosis interplayed with progressive chronic kidney disease (CKD). However, no available therapy is effective in suppressing progressive CKD. Here, using microbiomics in 480 participants including healthy controls and patients with stage 1-5 CKD, we identified an elongation taxonomic chain Bacilli-Lactobacillales-Lactobacillaceae-Lactobacillus-Lactobacillus johnsonii correlated with patients with CKD progression, whose abundance strongly correlated with clinical kidney markers. L. johnsonii abundance reduced with progressive CKD in rats with adenine-induced CKD. L. johnsonii supplementation ameliorated kidney lesion. Serum indole-3-aldehyde (IAld), whose…
Citation impact
- FWCI
- 24.27
- Percentile
- 100%
- References
- 56
Authors
15- HMHua Miao
Zhejiang Chinese Medical University
- FLFei LiuCorresponding
Macau University of Science and Technology, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, Chinese PLA General Hospital
- YWYanni Wang
Zhejiang Chinese Medical University
- XYXiao‐Yong Yu
Shaanxi Provincial Hospital of Traditional Chinese Medicine
- SZShougang Zhuang
Brown University, Rhode Island Hospital
Topics & keywords
- Kidney disease
- Kidney
- Renal function
- Internal medicine
- Creatinine
- Lesion
- Endocrinology
- Biology
- Good health and well-being