Glycosylation: mechanisms, biological functions and clinical implications
Shandong University · Shandong Provincial Hospital · +5 more institutions
Abstract
Protein post-translational modification (PTM) is a covalent process that occurs in proteins during or after translation through the addition or removal of one or more functional groups, and has a profound effect on protein function. Glycosylation is one of the most common PTMs, in which polysaccharides are transferred to specific amino acid residues in proteins by glycosyltransferases. A growing body of evidence suggests that glycosylation is essential for the unfolding of various functional activities in organisms, such as playing a key role in the regulation of protein function, cell adhesion and immune escape. Aberrant glycosylation is also closely associated with the development of various diseases.…
Citation impact
- FWCI
- 77.16
- Percentile
- 100%
- References
- 540
Authors
3- MHMengyuan HeCorresponding
Shandong University, Shandong Provincial Hospital
- XZXiangxiang Zhou
Soochow University, Shandong Provincial Hospital, First Affiliated Hospital of Soochow University, Shandong First Medical University
- XWXin Wang
Shandong University, Soochow University, National Clinical Research Center for Digestive Diseases, Shandong Provincial Hospital, Taishan University, First Affiliated Hospital of Soochow University, Shandong First Medical University
Topics & keywords
- Glycosylation
- Function (biology)
- Glycosyltransferase
- Computational biology
- Biology
- Biochemistry
- Immune system
- Chemistry
- Good health and well-being