Tumor battlefield within inflamed, excluded or desert immune phenotypes: the mechanisms and strategies

The tumor microenvironment demonstrates great immunophenotypic heterogeneity, which has been leveraged in traditional immune-hot/cold tumor categorization based on the abundance of intra-tumoral immune cells. By incorporating the spatial immune contexture, the tumor immunophenotype was further elaborated into immune-inflamed, immune-excluded, and immune-desert. However, the mechanisms underlying these different immune phenotypes are yet to be comprehensively elucidated. In this review, we discuss how tumor cells and the tumor microenvironment interact collectively to shape the immune landscape from the perspectives of tumor cells, immune cells, the extracellular matrix, and cancer metabolism, and we summarize…

• NN
  National Natural Science Foundation of China

  Awards: 82273275, 82073151
• FR
  Fundamental Research Funds for the Central Universities

  Award: 226-2024-00062
• NS
  Natural Science Foundation of Zhejiang Province

  Awards: LR19H160001, LGF21H160030