Prognostic genome and transcriptome signatures in colorectal cancers

. Here, to understand the functional and prognostic impact of cancer-causing somatic mutations, we analysed the whole genomes and transcriptomes of 1,063 primary colorectal cancers in a population-based cohort with long-term follow-up. From the 96 mutated driver genes, 9 were not previously implicated in colorectal cancer and 24 had not been linked to any cancer. Two distinct patterns of pathway co-mutations were observed, timing analyses identified nine early and three late driver gene mutations, and several signatures of colorectal-cancer-specific mutational processes were identified. Mutations in WNT, EGFR and TGFβ pathway genes, the mitochondrial CYB gene and 3 regulatory elements along with 21 copy-number…

• C
  Cancerfonden

  Awards: CAN 2018/772, 22 2054 Pj 01H, 2018/772
• KT
  Kungliga Tekniska Högskolan
• UU
  Umeå Universitet
• AS
  Akademiska Sjukhuset
• UU
  Uppsala Universitet
• SU
  Stockholms Universitet