reviewCellAug 1, 2024HYBRID OA

Guidelines for minimal information on cellular senescence experimentation in vivo

MOMikołaj OgrodnikJCJuan Carlos AcostaPDPeter D. AdamsFDFabrizio d’Adda di FagagnaDJDarren J. Baker

Ludwig Boltzmann Gesellschaft · Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA · +49 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Cellular senescence is a cell fate triggered in response to stress and is characterized by stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging from tissue repair to chronic disease. The development of new tools to study senescence in vivo has paved the way for uncovering its physiological and pathological roles and testing senescent cells as a therapeutic target. However, the lack of specific and broadly applicable markers makes it difficult to identify and characterize senescent cells in tissues and living organisms. To address this, we provide practical guidelines called "minimum information for cellular senescence experimentation in vivo" (MICSE). It presents an…

Citation impact

264
total citations
FWCI
78.46
Percentile
100%
References
169
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Authors

32

Topics & keywords

Topics
Keywords
  • Biology
  • Senescence
  • In vivo
  • Cell biology
  • Cellular senescence
  • Computational biology
  • Genetics
  • Phenotype
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