LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity
University of Pittsburgh · UPMC Hillman Cancer Center · +4 more institutions
Indexed incrossrefpubmed
Abstract
No abstract available for this paper.
Citation impact
227
total citations
- FWCI
- 57.01
- Percentile
- 100%
- References
- 66
Citations per year
Authors
20- LPLawrence P. Andrews
University of Pittsburgh, UPMC Hillman Cancer Center
- SCSamuel C. Butler
UPMC Hillman Cancer Center, University of Pittsburgh
- JCJian Cui
University of Pittsburgh, UPMC Hillman Cancer Center
- ARAnthony R. Cillo
UPMC Hillman Cancer Center, University of Pittsburgh
- CCCarly Cardello
University of Pittsburgh, UPMC Hillman Cancer Center
Topics & keywords
Topics
Keywords
- Biology
- Autocrine signalling
- Immunity
- Immunology
- CD8
- Cytotoxic T cell
- Cancer research
- Interferon gamma
No related works found for this paper.
Funding
- BSBristol-Myers SquibbAward: BMS-CA224-070
- FFibroGen
- UOUniversity of Pennsylvania
- UOUniversity of PittsburghAwards: SCR_022735, S10OD028483
- PIParker Institute for Cancer Immunotherapy
- NINational Institutes of HealthAwards: AI155577, 75N93020D00005, P01 AI108545, CA263850, CA236749, AI56299, AI115712, AI144422, CA254865, CA210944, AI108545, AI117950, AI082630, S10OD028483
- CFCenter for Research Computing, University of PittsburghAward: SCR_022735
- NHNational Health and Medical Research CouncilAward: GNT1111469