articleAnalytical ChemistryAug 10, 2024HYBRID OA

Bimetallic Single-Atom Nanozyme-Based Electrochemical-Photothermal Dual-Function Portable Immunoassay with Smartphone Imaging

YWYunsen WangRZRuijin ZengSTShuo TianSCShuyun ChenZBZhilan Bi

Fuzhou University · Technical University of Munich

PubMed
Indexed incrossrefpubmed

Abstract

Rapid and accurate detection of human epidermal growth factor receptor 2 (HER2) is crucial for the early diagnosis and prognosis of breast cancer. In this study, we reported an iron–manganese ion N-doped carbon single-atom catalyst (FeMn-NCetch/SAC) bimetallic peroxidase mimetic enzyme with abundant active sites etched by H2O2 and further demonstrated unique advantages of single-atom bimetallic nanozymes in generating hydroxyl radicals by density functional theory (DFT) calculations. As a proof of concept, a portable device-dependent electrochemical-photothermal bifunctional immunoassay detection platform was designed to achieve reliable detection of HER2. In the enzyme-linked reaction, H2O2 was generated by…

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197
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Authors

7

Topics & keywords

Topics
Keywords
  • Chemistry
  • Bimetallic strip
  • Photothermal therapy
  • Human Epidermal Growth Factor Receptor 2
  • Atom (system on chip)
  • Immunoassay
  • Manganese
  • Electrochemistry
UN Sustainable Development Goals
  • Affordable and clean energy
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