Macrophage-mediated myelin recycling fuels brain cancer malignancy

Tumors growing in metabolically challenged environments, such as glioblastoma in the brain, are particularly reliant on crosstalk with their tumor microenvironment (TME) to satisfy their high energetic needs. To study the intricacies of this metabolic interplay, we interrogated the heterogeneity of the glioblastoma TME using single-cell and multi-omics analyses and identified metabolically rewired tumor-associated macrophage (TAM) subpopulations with pro-tumorigenic properties. These TAM subsets, termed lipid-laden macrophages (LLMs) to reflect their cholesterol accumulation, are epigenetically rewired, display immunosuppressive features, and are enriched in the aggressive mesenchymal glioblastoma subtype.…

• CG
  Cancer Genomics Centre
• NO
  Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Awards: ENW-XL 21-XL21-071, 91719355
• KK
  KWF Kankerbestrijding

  Awards: 2021-14339, 2022-14530, 2017-10658
• AE
  Aard- en Levenswetenschappen, Nederlandse Organisatie voor Wetenschappelijk Onderzoek
• OI
  Oncode Institute
• ER
  European Research Council
• HE
  H2020 European Research Council

  Award: SYN 101118999