H3K18 Lactylation Potentiates Immune Escape of Non–Small Cell Lung Cancer
Henan Energy & Chemical Industry Group (China) · First Affiliated Hospital of Zhengzhou University · +1 more institution
Abstract
Recently discovered epigenetic modification lysine lactylation contributes to tumor development and progression in several types of cancer. In addition to the tumor-intrinsic effects, histone lactylation may mediate tumor microenvironment remodeling and immune evasion. In this study, we observed elevated pan-lysine lactylation and histone H3 lysine 18 lactylation (H3K18la) levels in non-small cell lung cancer (NSCLC) tissues, which was positively correlated with poor patient prognosis. Interruption of glycolysis by 2-deoxy-D-glucose and oxamate treatment and silencing of lactate dehydrogenase A and lactate dehydrogenase B reduced H3K18la levels and circumvented immune evasion of NSCLC cells by enhancing CD8+…
Citation impact
- FWCI
- 43.63
- Percentile
- 100%
- References
- 47
Authors
7- CZCai ZhangCorresponding
Henan Energy & Chemical Industry Group (China), First Affiliated Hospital of Zhengzhou University
- LZLijie Zhou
First Affiliated Hospital of Zhengzhou University
- MZMingyuan Zhang
Zhengzhou University
- YDYue Du
Zhengzhou University
- CLCai Li
First Affiliated Hospital of Zhengzhou University
Topics & keywords
- Cancer research
- Immune system
- Tumor microenvironment
- Carcinogenesis
- Lung cancer
- CD8
- Immunotherapy
- Epigenetics
- Good health and well-being