Nanoarchitectonics of in Situ Antibiotic-Releasing Acicular Nanozymes for Targeting and Inducing Cuproptosis-like Death to Eliminate Drug-Resistant Bacteria

A series of progress has been made in the field of antimicrobial use of nanozymes due to their superior stability and decreased susceptibility to drug resistance. However, catalytically generated reactive oxygen species (ROS) are insufficient for coping with multidrug-resistant organisms (MDROs) in complex wound environments due to their low targeting ability and insufficient catalytic activity. To address this problem, chemically stable copper–gallic acid–vancomycin (CuGA–VAN) nanoneedles were successfully constructed by a simple approach for targeting bacteria; these nanoneedles exhibit OXD-like and GSH-px-like dual enzyme activities to produce ROS and induce bacterial cuproptosis-like death, thereby…

• NN
  National Natural Science Foundation of China

  Awards: 82172204, 82372517, 82372552
• AM
  Anhui Medical University

  Award: 2021xkjT028
• NS
  Natural Science Foundation of Anhui Province

  Award: 2208085QC81
• UN
  University Natural Science Research Project of Anhui Province

  Award: 2023AH030060
• AP
  Anhui Provincial Key Research and Development Plan

  Award: 202104j07020027