Mammalian copper homeostasis: physiological roles and molecular mechanisms

In the past decade, evidence for the numerous roles of copper (Cu) in mammalian physiology has grown exponentially. The discoveries of Cu involvement in cell signaling, autophagy, cell motility, differentiation, and regulated cell death (cuproptosis) have markedly extended the list of already known functions of Cu, such as a cofactor of essential metabolic enzymes, a protein structural component, and a regulator of protein trafficking. Novel and unexpected functions of Cu transporting proteins and enzymes have been identified, and new disorders of Cu homeostasis have been described. Significant progress has been made in the mechanistic studies of two classic disorders of Cu metabolism, Menkes disease and…

• OO
  Office of Naval Research

  Award: N00014-23-1-2465
• NC
  National Cancer Institute

  Award: R01CA279550
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Awards: R01DK117396, R01DK071865
• NI
  National Institute of Neurological Disorders and Stroke

  Award: R01NS134958