reviewThe Lancet Regional Health - EuropeAug 23, 2024GOLD OA

Multiple sclerosis: emerging epidemiological trends and redefining the clinical course

EPEmilio PortaccioMMMelinda MagyariEHEva HavrdováARAurélie RuetBBBruno Brochet

University of Florence · Copenhagen University Hospital · +12 more institutions

PubMed
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Abstract

Multiple sclerosis is a chronic, inflammatory, and neurodegenerative disease of the central nervous system and a major cause of neurological disability in young adults. Its prevalence and incidence are increasing, and it has been estimated at over 2.8 million cases worldwide, in addition to recent trends towards a shift in MS prevalence to older ages, with peak prevalence estimates in the sixth decade of life. Although historically the relapsing and progressive phases of the disease have been considered separate clinical entities, recent evidence of progression independent of relapse activity (PIRA) has led to a reconsideration of multiple sclerosis as a continuum, in which relapsing and progressive features…

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125
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100%
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Authors

10

Topics & keywords

Topics
Keywords
  • Disease
  • Epidemiology
  • Multiple sclerosis
  • Medicine
  • Clinical epidemiology
  • Life course approach
  • Clinical disease
  • Intensive care medicine
UN Sustainable Development Goals
  • Good health and well-being
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