Renal tubular epithelial cells response to injury in acute kidney injury

Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid and significant decrease in renal function that can arise from various etiologies, and is associated with high morbidity and mortality. The renal tubular epithelial cells (TECs) represent the central cell type affected by AKI, and their notable regenerative capacity is critical for the recovery of renal function in afflicted patients. The adaptive repair process initiated by surviving TECs following mild AKI facilitates full renal recovery. Conversely, when injury is severe or persistent, it allows the TECs to undergo pathological responses, abnormal adaptive repair and phenotypic transformation, which will lead to the development of…

• NN
  National Natural Science Foundation of China

  Awards: 82241045, 82122011, 82030024, 82000648, 82230022
• NU
  National University's Basic Research Foundation of China
• NK
  National Key Research and Development Program of China

  Award: 2022YFC2502500
• FR
  Fundamental Research Funds for the Central Universities

  Award: 2242023K40046