reviewEBioMedicineAug 23, 2024GOLD OA

Reprogramming the immunosuppressive tumor microenvironment through nanomedicine: an immunometabolism perspective

JLJieyu LiuYBYinan BaiYLYinggang LiXLXiaoling LiKLKui Luo

Sichuan University · West China Hospital of Sichuan University · +2 more institutions

PubMed
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Abstract

Increasing evidence indicates that immunotherapy is hindered by a hostile tumor microenvironment (TME) featured with deprivation of critical nutrients and pooling of immunosuppressive metabolites. Tumor cells and immunosuppressive cells outcompete immune effector cells for essential nutrients. Meanwhile, a wide range of tumor cell-derived toxic metabolites exerts negative impacts on anti-tumor immune response, diminishing the efficacy of immunotherapy. Nanomedicine with excellent targetability offers a novel approach to improving cancer immunotherapy via metabolically reprogramming the immunosuppressive TME. Herein, we review recent strategies of enhancing immunotherapeutic effects through rewiring tumor…

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145
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FWCI
32.30
Percentile
100%
References
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Authors

5

Topics & keywords

Topics
Keywords
  • Tumor microenvironment
  • Immunotherapy
  • Reprogramming
  • Immune system
  • Cancer immunotherapy
  • Nanomedicine
  • Cancer research
  • Stromal cell
UN Sustainable Development Goals
  • Zero hunger
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