Microneedles as transdermal drug delivery system for enhancing skin disease treatment

Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding a viable resolution to the formidable barriers presented by the cutaneous interface. This review examines MNs as an advanced approach to enhancing dermatological pathology management. It explores the complex dermis structure and highlights the limitations of traditional transdermal methods, emphasizing MNs' advantage in bypassing the stratum corneum to deliver drugs directly to the subdermal matrix. The discourse outlines the diverse typologies of MNs, including solid, coated, hollow, hydrogel, and dissolvable versions. Each type is characterized by its unique applications and benefits. The treatise details the…

• NN
  National Natural Science Foundation of China

  Awards: 82072059, 2021-I2M-1-058, 82172090, 82302390
• CP
  China Postdoctoral Science Foundation

  Award: 2022M720502
• NS
  Natural Science Foundation of Tianjin City

  Award: 22JCQNJC00070
• FR
  Fundamental Research Funds for the Central Universities

  Award: 2019PT320028