Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations

Moguilner, Sebastián; Báez, Sandra; Hernandez, Hernán; Migeot, Joaquín; Legaz, Agustina; González-Gómez, Raúl; Farina, Francesca R; Prado, Pavel; Cuadros, Jhosmary; Tagliazucchi, Enzo; Altschuler, Florencia; Maito, Marcelo Adrián; Godoy, Maria Eugenia; Cruzat, Josephine; Valdés‐Sosa, Pedro A.; Lopera, Francisco; Ochoa-Gómez, John Fredy; González‐Hernández, Alfredis; Bonilla‐Santos, Jasmin; Gonzalez‐Montealegre, Rodrigo A.; Anghinah, Renato; Manfrinati, Luís E. d’Almeida; Fittipaldi, Sol; Medel, Vicente; Olivares, Daniela; Yener, Görsev; Escudero, Javier; Babiloni, Claudio; Whelan, Robert; Güntekin, Bahar; Yırıkoğulları, Harun; Santamaría‐García, Hernando; Lucas, Alberto Fernández; Huepe, David; Caterina, Gaetano Di; Soto‐Añari, Marcio; Birba, Agustina; Sainz‐Ballesteros, Agustín; Coronel‐Oliveros, Carlos; Yigezu, Amanuel; Herrera, Eduar; Abásolo, Daniel; Kilborn, Kerry; Rubido, Nicolás; Clark, Ruaridh; Herzog, Rubén; Yerlikaya, Deniz; Hu, Kun; Parra, Mario A.; Reyes, Pablo; García, Adolfo M.; Matallana, Diana; Ávila‐Funes, José Alberto; Slachevsky, Andrea; Behrens, María Isabel; Custodio, Nilton; Cardona, Juan F.; Barttfeld, Pablo; Brusco, Ignacio L.; Bruno, Martín A.; Ortiz, Ana L. Sosa; Piña‐Escudero, Stefanie Danielle; Takada, Leonel Tadao; Resende, Elisa de Paula França; Possin, Katherine L.; Oliveira, Maira Okada de; Valdés, Alejandro López; Lawlor, Brian; Robertson, Ian H.; Kosik, Kenneth S.; Duran‐Aniotz, Claudia; Valcour, Victor; Yokoyama, Jennifer S.; Miller, Bruce; Ibáñez, Agustín

doi:10.1038/s41591-024-03209-x

articleNature MedicineAug 26, 2024HYBRID OA

Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations

SMSebastián Moguilner SBSandra Báez HHHernán Hernandez JMJoaquín Migeot ALAgustina Legaz

Harvard University · Adolfo Ibáñez University · +60 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Brain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding brain health and disease. However, the impact of diversity (including geographical, socioeconomic, sociodemographic, sex and neurodegeneration) on the brain-age gap is unknown. We analyzed datasets from 5,306 participants across 15 countries (7 Latin American and Caribbean countries (LAC) and 8 non-LAC countries). Based on higher-order interactions, we developed a brain-age gap deep learning architecture for functional magnetic resonance imaging (2,953) and electroencephalography (2,353). The datasets comprised healthy controls and individuals with mild cognitive impairment, Alzheimer disease and…

Citation impact

112

total citations

FWCI: 34.95
Percentile: 100%
References: 85

Citations per year

Authors

75

Topics & keywords

Topics

Keywords

Dementia
Socioeconomic status
Functional magnetic resonance imaging
Audiology
Brain activity and meditation
Cognitive decline
Medicine
Gerontology

No related works found for this paper.