Sepsis Biomarkers: Advancements and Clinical Applications—A Narrative Review
Tianjin University of Traditional Chinese Medicine · Guangdong Pharmaceutical University · +2 more institutions
Abstract
Sepsis is now defined as a life-threatening syndrome of organ dysfunction triggered by a dysregulated host response to infection, posing significant challenges in critical care. The main objective of this review is to evaluate the potential of emerging biomarkers for early diagnosis and accurate prognosis in sepsis management, which are pivotal for enhancing patient outcomes. Despite advances in supportive care, traditional biomarkers like C-reactive protein and procalcitonin have limitations, and recent studies have identified novel biomarkers with increased sensitivity and specificity, including circular RNAs, HOXA distal transcript antisense RNA, microRNA-486-5p, protein C, triiodothyronine, and…
Citation impact
- FWCI
- 39.19
- Percentile
- 100%
- References
- 154
Authors
5- RHRong‐Rong He
Tianjin University of Traditional Chinese Medicine
- GYGuo-Li Yue
Tianjin University of Traditional Chinese Medicine
- MDMei-Ling Dong
Guangdong Pharmaceutical University, Chinese Academy of Sciences, Shanghai Institute of Materia Medica
- JWJiaqi Wang
Chinese Academy of Sciences, Shanghai Institute of Materia Medica
- CCChen ChengCorresponding
Guangdong Pharmaceutical University, Chinese Academy of Sciences, Shanghai Institute of Materia Medica
Topics & keywords
- Procalcitonin
- Biomarker
- Sepsis
- Intensive care medicine
- Medicine
- Precision medicine
- Personalized medicine
- Bioinformatics