reviewActa Pharmaceutica Sinica BSep 2, 2024DIAMOND OA

Solubilization techniques used for poorly water-soluble drugs

BXBing XieYLYaping LiuXLXiaotong LiPYPei YangWHWei He

China Pharmaceutical University · Tongji University · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

About 40% of approved drugs and nearly 90% of drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving the solubility and bioavailability of poorly water-soluble drugs is a critical issue that needs to be urgently addressed in drug development and application. This review briefly introduces the conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, and details the crystallization strategies, ionic liquids, and polymer-based, lipid-based, and inorganic-based carriers in improving solubility and bioavailability. Some of the most commonly used…

Citation impact

136
total citations
FWCI
25.38
Percentile
100%
References
574
Citations per year

Authors

5

Topics & keywords

Topics
Keywords
  • Solubilization
  • Water soluble
  • Chemistry
  • Computer science
  • Pharmacology
  • Chromatography
  • Medicine
  • Biochemistry
UN Sustainable Development Goals
  • Clean water and sanitation
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