LIANA+ provides an all-in-one framework for cell–cell communication inference

The growing availability of single-cell and spatially resolved transcriptomics has led to the development of many approaches to infer cell-cell communication, each capturing only a partial view of the complex landscape of intercellular signalling. Here we present LIANA+, a scalable framework built around a rich knowledge base to decode coordinated inter- and intracellular signalling events from single- and multi-condition datasets in both single-cell and spatially resolved data. By extending and unifying established methodologies, LIANA+ provides a comprehensive set of synergistic components to study cell-cell communication via diverse molecular mediators, including those measured in multi-omics data. LIANA+…

• P
  Pfizer
• EC
  European Commission

  Awards: 860329, 965193, 951773
• DF
  Deutsche Forschungsgemeinschaft

  Awards: SFB 1550, SPP 2395, CRC/SFB 1550