Metabolic reprogramming and immune evasion: the interplay in the tumor microenvironment
Central South University · Hunan Cancer Hospital · +1 more institution
Abstract
Tumor cells possess complex immune evasion mechanisms to evade immune system attacks, primarily through metabolic reprogramming, which significantly alters the tumor microenvironment (TME) to modulate immune cell functions. When a tumor is sufficiently immunogenic, it can activate cytotoxic T-cells to target and destroy it. However, tumors adapt by manipulating their metabolic pathways, particularly glucose, amino acid, and lipid metabolism, to create an immunosuppressive TME that promotes immune escape. These metabolic alterations impact the function and differentiation of non-tumor cells within the TME, such as inhibiting effector T-cell activity while expanding regulatory T-cells and myeloid-derived…
Citation impact
- FWCI
- 30.31
- Percentile
- 100%
- References
- 268
Authors
10- HZHaixia ZhangCorresponding
Central South University, Hunan Cancer Hospital, Third Xiangya Hospital
- SLShizhen Li
Central South University, Hunan Cancer Hospital
- DWDan Wang
Central South University, Third Xiangya Hospital
- SLSiyang Liu
Central South University, Third Xiangya Hospital
- TXTengfei Xiao
Central South University, Hunan Cancer Hospital
Topics & keywords
- Tumor microenvironment
- Immune system
- Immunotherapy
- Biology
- Chemokine
- Cancer immunotherapy
- Cancer cell
- Cancer research
- Good health and well-being