Updates in Alzheimer's disease: from basic research to diagnosis and therapies
First Affiliated Hospital of Zhengzhou University · Huazhong University of Science and Technology · +1 more institution
Abstract
Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized pathologically by extracellular deposition of β-amyloid (Aβ) into senile plaques and intracellular accumulation of hyperphosphorylated tau (pTau) as neurofibrillary tangles. Clinically, AD patients show memory deterioration with varying cognitive dysfunctions. The exact molecular mechanisms underlying AD are still not fully understood, and there are no efficient drugs to stop or reverse the disease progression. In this review, we first provide an update on how the risk factors, including APOE variants, infections and inflammation, contribute to AD; how Aβ and tau become abnormally accumulated and how this accumulation plays a…
Citation impact
- FWCI
- 43.53
- Percentile
- 100%
- References
- 621
Authors
3Topics & keywords
- Neurodegeneration
- Disease
- Senile plaques
- Neuroscience
- Medicine
- Neurology
- Tau protein
- Amyloid (mycology)
- Good health and well-being