Biodegradable Polymeric Nanoparticle-Based Drug Delivery Systems: Comprehensive Overview, Perspectives and Challenges
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Abstract
In the last few decades, there has been a growing interest in the use of biodegradable polymeric nanoparticles (BPNPs) as the carriers for various therapeutic agents in drug delivery systems. BPNPs have the potential to improve the efficacy of numerous active agents by facilitating targeted delivery to a desired site in the body. Biodegradable polymers are especially promising nanocarriers for therapeutic substances characterized by poor solubility, instability, rapid metabolism, and rapid system elimination. Such molecules can be efficiently encapsulated and subsequently released from nanoparticles, which greatly improves their stability and bioavailability. Biopolymers seem to be the most suitable candidates…
Citation impact
158
total citations
- FWCI
- 24.70
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- 100%
- References
- 148
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Authors
2Topics & keywords
Topics
Keywords
- Nanocarriers
- Drug delivery
- Nanotechnology
- Biocompatibility
- Biodegradable polymer
- Materials science
- Nanoparticle
- Flexibility (engineering)
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