articleAngewandte Chemie International EditionSep 10, 2024Closed access

D‐Band‐Center‐Engineered Platinum‐Based Nanozyme for Personalized Pharmacovigilance

ZYZhichao YuZXZhenjin XuRZRuijin ZengMXMan XuHZHaisu Zheng

Fuzhou University · King University · +4 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Abstract A high‐efficiency PtZnCd nanozyme was screened with density functional theory (DFT) and unique d‐orbital coupling features for sensitive enrichment and real‐time analysis of CO‐releasing molecule‐3 (CORM‐3). Multicatalytic sites in the nanozyme showed a high reactivity of up to 72.89 min −1 for peroxidase (POD)‐like reaction, which was 2.2, 4.07, and 14.67 times higher than that of PtZn (32.67 min −1 ), PtCd (17.89 min −1 ), and Pt (4.97 min −1 ), respectively. Normalization of the catalytic sites showed that the catalytic capacity of the active site in PtZnCd was 2.962 U μmol −1 , which was four times higher than that of a pure Pt site (0.733 U μmol −1 ). DFT calculations showed that improved…

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Topics & keywords

Topics
Keywords
  • Catalysis
  • Density functional theory
  • Chemistry
  • Active site
  • Electron transfer
  • Active center
  • Molecule
  • Osmium
UN Sustainable Development Goals
  • Affordable and clean energy
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