Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy
National Cancer Institute · Leibniz Institute for Immunotherapy · +16 more institutions
Indexed incrossrefpubmed
Abstract
T cells mediated superior antitumor responses, prolonging animal survival. These findings establish intercellular mitochondrial transfer as a prototype of organelle medicine, opening avenues to next-generation cell therapies.
Citation impact
191
total citations
- FWCI
- 32.09
- Percentile
- 100%
- References
- 79
Citations per year
Authors
30Topics & keywords
Topics
Keywords
- Biology
- Intracellular
- Mitochondrion
- Cell biology
- Cell
- Biochemistry
UN Sustainable Development Goals
- Zero hunger
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Funding
- FAFondazione AIRC per la ricerca sul cancro ETS
- CRCancer Research Institute
- GSGilead Sciences
- JHJoachim Herz Stiftung
- UFUS-UK Fulbright Commission
- ECEuropean CommissionAwards: 725038, 957502, 964481, PE00000007
- FAFulbright Australia
- DFDeutsche ForschungsgemeinschaftAward: 401821119
- BFBundesministerium für Bildung und ForschungAward: 01KI2013
- EKElse Kröner-Fresenius-Stiftung
- MDMinistero della SaluteAwards: 2018-, RF-2018, RF-2018-12365801, PE00000007
- AIAssociazione Italiana per la Ricerca sul CancroAwards: 22737, 19891, 26183
- KFKinghorn Foundation
- NINational Institutes of Health
- EREuropean Research Council
- LLeibniz-Gemeinschaft
- NCNational Cancer Institute
- HEHORIZON EUROPE European Innovation Council