Biodegradable Piezoelectric‐Conductive Integrated Hydrogel Scaffold for Repair of Osteochondral Defects
Peking University · Peking University Third Hospital · +2 more institutions
Abstract
Osteochondral injury is a prevalent condition for which no specific treatment is currently available. This study presents a piezoelectric-conductive scaffold composed of a piezoelectric cartilage-decellularized extracellular matrix (dECM) and piezoelectric-conductive modified gelatin (Gel-PC). The piezoelectricity of the scaffold is achieved through the modification of diphenylalanine (FF) assembly on the pore surface, while the conductive properties of scaffold are achieved by the incorporating poly(3,4-ethylenedioxythiophene). In vitro experiments demonstrate that bone marrow mesenchymal stem cells (BMSCs) undergo biphasic division during differentiation. In vivo studies using a Parma pig model of…
Citation impact
- FWCI
- 45.61
- Percentile
- 100%
- References
- 53
Authors
12Topics & keywords
- Materials science
- Scaffold
- Piezoelectricity
- Electrical conductor
- Tissue engineering
- Composite material
- Nanotechnology
- Biomedical engineering