Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer
Sun Yat-sen University · Chinese University of Hong Kong, Shenzhen · +7 more institutions
Abstract
T cell exhaustion and promoting effector function. Supporting this notion, knockout of a butyric acid-producing gene in Fn abolishes its anti-PD-1 boosting effect. In patients with MSS CRC, high intratumoral Fn predicts favorable response to anti-PD-1 therapy, indicating Fn as a potential biomarker of immunotherapy response in MSS CRC.
Citation impact
- FWCI
- 45.12
- Percentile
- 100%
- References
- 50
Authors
24- XWXueliang WangCorresponding
Sun Yat-sen University, Chinese University of Hong Kong, Shenzhen, The First Affiliated Hospital, Sun Yat-sen University
- YQY. Q. Fang
Sun Yat-sen University, The First Affiliated Hospital, Sun Yat-sen University
- WLWei Liang
Sun Yat-sen University, The First Affiliated Hospital, Sun Yat-sen University
- CCChi Chun Wong
Chinese University of Hong Kong, Chinese University of Hong Kong, Shenzhen
- HQHuanlong Qin
Tongji University, Shanghai Tenth People's Hospital
Topics & keywords
- Fusobacterium nucleatum
- Colorectal cancer
- Microsatellite instability
- Medicine
- Cancer research
- Cancer
- Biology
- Microsatellite
- Good health and well-being