Neutrophil extracellular traps in homeostasis and disease
Tongji Hospital · Huazhong University of Science and Technology · +2 more institutions
Abstract
Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are renowned for their propensity to expel decondensed chromatin embedded with inflammatory proteins. Our comprehension of NETs in pathogen clearance, immune regulation and disease pathogenesis, has grown significantly in recent years. NETs are not only pivotal in the context of infections but also exhibit significant involvement in sterile inflammation. Evidence suggests that excessive accumulation of NETs can result in vessel occlusion, tissue damage, and prolonged inflammatory responses, thereby contributing to the progression and exacerbation of various pathological states. Nevertheless, NETs exhibit dual functionalities in…
Citation impact
- FWCI
- 79.50
- Percentile
- 100%
- References
- 729
Authors
8- HWHan WangCorresponding
Tongji Hospital, Huazhong University of Science and Technology
- SJSusan J. Kim
University of Virginia
- LYLei Yu
Tongji Hospital, Huazhong University of Science and Technology
- SWShuhui Wang
Tongji Hospital, Huazhong University of Science and Technology
- HWHui Wang
Tongji Hospital, Huazhong University of Science and Technology
Topics & keywords
- Neutrophil extracellular traps
- Proinflammatory cytokine
- Inflammation
- Immune system
- Immunology
- Context (archaeology)
- Biology
- Homeostasis
- Good health and well-being