The Nrf2-HO-1 system and inflammaging
Trinity College Dublin · Advanced Materials and BioEngineering Research
Abstract
Nrf2 is a master transcriptional regulator of a number of genes involved in the adaptive response to oxidative stress. Among the genes upregulated by Nrf2, heme oxygenase-1 (HO-1) has received significant attention, given that the products of HO-1-induced heme catabolism have well established antioxidant and anti-inflammatory properties. This is evidenced in numerous models of inflammatory and autoimmune disease whereby induction of HO-1 expression or administration of tolerable amounts of HO-1 reaction products can ameliorate disease symptoms. Unsurprisingly, Nrf2 and HO-1 are now considered viable drug targets for a number of conditions. In recent years, the term ‘inflammaging’ has been used to describe the…
Citation impact
- FWCI
- 35.13
- Percentile
- 100%
- References
- 131
Authors
3Topics & keywords
- Oxidative stress
- Heme oxygenase
- Disease
- Inflammation
- Senescence
- Heme
- Downregulation and upregulation
- Regulator
- Good health and well-being