reviewPolymersSep 14, 2024GOLD OA

Recent Applications of PLGA in Drug Delivery Systems

JYJie YangHZHuiying ZengYLYusheng LuoYCYing ChenMWMiao Wang

Jinan University · Guangdong Institute for Drug Control

PubMed
Indexed incrossrefdoajpubmed

Abstract

Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable and biocompatible copolymer in drug delivery systems (DDSs). In this article, we highlight the critical physicochemical properties of PLGA, including its molecular weight, intrinsic viscosity, monomer ratio, blockiness, and end caps, that significantly influence drug release profiles and degradation times. This review also covers the extensive literature on the application of PLGA in delivering small-molecule drugs, proteins, peptides, antibiotics, and antiviral drugs. Furthermore, we discuss the role of PLGA-based DDSs in the treating various diseases, including cancer, neurological disorders, pain, and inflammation. The incorporation of…

Citation impact

173
total citations
FWCI
32.12
Percentile
100%
References
151
Citations per year

Authors

7

Topics & keywords

Topics
Keywords
  • PLGA
  • Glycolic acid
  • Drug delivery
  • Drug
  • Nanotechnology
  • Polyester
  • Biocompatible material
  • Pharmacology
UN Sustainable Development Goals
  • Good health and well-being
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