Mechanisms of long COVID and the path toward therapeutics
University of California, San Francisco
Abstract
Long COVID, a type of post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PASC) defined by medically unexplained symptoms following infection with SARS-CoV-2, is a newly recognized infection-associated chronic condition that causes disability in some people. Substantial progress has been made in defining its epidemiology, biology, and pathophysiology. However, there is no cure for the tens of millions of people believed to be experiencing long COVID, and industry engagement in developing therapeutics has been limited. Here, we review the current state of knowledge regarding the biology and pathophysiology of long COVID, focusing on how the proposed mechanisms explain the…
Citation impact
- FWCI
- 90.64
- Percentile
- 100%
- References
- 335
Authors
2Topics & keywords
- Biology
- Coronavirus disease 2019 (COVID-19)
- 2019-20 coronavirus outbreak
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Path (computing)
- Betacoronavirus
- Pandemic
- Coronavirus Infections
- Zero hunger