reviewJournal of Extracellular VesiclesSep 27, 2024GOLD OA

A critical systematic review of extracellular vesicle clinical trials

RRRachel R. MizenkoMFMadison FeaverBTBatuhan Turhan BozkurtNLNeona LoweBNBryan Nguyen

University of California, Davis

PubMed
Indexed incrossrefdoajpubmed

Abstract

This systematic review examines the landscape of extracellular vesicle (EV)-related clinical trials to elucidate the field's trends in clinical applications and EV-related methodologies, with an additional focus on the acknowledgement of EV subpopulations. By analysing data from public reporting repositories, we catalogued 471 EV-related clinical trials to date, with indications for over 200 diseases. Diagnostics and companion diagnostics represented the bulk of EV-related clinical trials with cancer being the most frequent application. EV-related therapeutics trials mainly utilized mesenchymal stromal cell (MSC) EVs and were most frequently used for treatment of respiratory illnesses. Ultracentrifugation and…

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137
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28.74
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100%
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82
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Authors

8

Topics & keywords

Topics
Keywords
  • Clinical trial
  • Extracellular vesicles
  • Extracellular vesicle
  • Medicine
  • Characterization (materials science)
  • Nanotechnology
  • Computational biology
  • Medical physics
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