Biological function of sialic acid and sialylation in human health and disease
Sun Yat-sen University · The First Affiliated Hospital, Sun Yat-sen University · +6 more institutions
Abstract
Abstract Sialic acids are predominantly found at the terminal ends of glycoproteins and glycolipids and play key roles in cellular communication and function. The process of sialylation, a form of post-translational modification, involves the covalent attachment of sialic acid to the terminal residues of oligosaccharides and glycoproteins. This modification not only provides a layer of electrostatic repulsion to cells but also serves as a receptor for various biological signaling pathways. Sialylation is involved in several pathophysiological processes. Given its multifaceted involvement in cellular functions, sialylation presents a promising avenue for therapeutic intervention. Current studies are exploring…
Citation impact
- FWCI
- 29.79
- Percentile
- 100%
- References
- 255
Authors
4- WZWengen Zhu
Sun Yat-sen University, The First Affiliated Hospital, Sun Yat-sen University
- YZYue Zhou
Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University
- LGLinjuan GuoCorresponding
First Affiliated Hospital of Jiangxi Medical College, Jiangxi Provincial People's Hospital
- SFShenghui Feng
Chinese Academy of Medical Sciences & Peking Union Medical College, Fu Wai Hospital
Topics & keywords
- Sialic acid
- Glycoprotein
- Function (biology)
- Disease
- Receptor
- Biochemistry
- Cell biology
- Chemistry
- Good health and well-being