Mechanisms of antimicrobial resistance in biofilms
University of East Anglia · Norwich Research Park · +2 more institutions
Abstract
Most bacteria in nature exist in aggregated communities known as biofilms, and cells within a biofilm demonstrate major physiological changes compared to their planktonic counterparts. Biofilms are associated with many different types of infections which can have severe impacts on patients. Infections involving a biofilm component are often chronic and highly recalcitrant to antibiotic therapy as a result of intrinsic physical factors including extracellular matrix production, low growth rates, altered antibiotic target production and efficient exchange of resistance genes. This review describes the biofilm lifecycle, phenotypic characteristics of a biofilm, and contribution of matrix and persister cells to…
Citation impact
- FWCI
- 72.53
- Percentile
- 100%
- References
- 132
Authors
3Topics & keywords
- Biofilm
- Antimicrobial
- Microbiology
- Antibiotic resistance
- Resistance (ecology)
- Biology
- Bacteria
- Antibiotics