reviewCancer DiscoveryOct 4, 2024Closed access

The Epigenetic Hallmarks of Cancer

MEManel EstellerMAMark A. DawsonCKCigall KadochFVFeyruz V. RassoolPAPeter A. Jones

Institució Catalana de Recerca i Estudis Avançats · Josep Carreras Leukaemia Research Institute · +13 more institutions

PubMed
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Abstract

Cancer is a complex disease in which several molecular and cellular pathways converge to foster the tumoral phenotype. Notably, in the latest iteration of the cancer hallmarks, "nonmutational epigenetic reprogramming" was newly added. However, epigenetics, much like genetics, is a broad scientific area that deserves further attention due to its multiple roles in cancer initiation, progression, and adaptive nature. Herein, we present a detailed examination of the epigenetic hallmarks affected in human cancer, elucidating the pathways and genes involved, and dissecting the disrupted landscapes for DNA methylation, histone modifications, and chromatin architecture that define the disease. Significance: Cancer is…

Citation impact

123
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FWCI
25.80
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100%
References
324
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Authors

6

Topics & keywords

Topics
Keywords
  • Epigenetics
  • Reprogramming
  • Biology
  • Chromatin
  • Cancer
  • Histone
  • DNA methylation
  • Disease
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