Metabolic regulation of the immune system in health and diseases: mechanisms and interventions

Metabolism, including glycolysis, oxidative phosphorylation, fatty acid oxidation, and other metabolic pathways, impacts the phenotypes and functions of immune cells. The metabolic regulation of the immune system is important in the pathogenesis and progression of numerous diseases, such as cancers, autoimmune diseases and metabolic diseases. The concept of immunometabolism was introduced over a decade ago to elucidate the intricate interplay between metabolism and immunity. The definition of immunometabolism has expanded from chronic low-grade inflammation in metabolic diseases to metabolic reprogramming of immune cells in various diseases. With immunometabolism being proposed and developed, the metabolic…

• SU
  Sichuan University

  Award: ZYGD23030
• NK
  National Key Research and Development Program of China

  Award: 2022YFC2304800
• WC
  West China Hospital, Sichuan University

  Awards: 1.3.5 project, ZYGD23030, 2022YFC2304800, 1.3.5