Intermetallics triggering pyroptosis and disulfidptosis in cancer cells promote anti-tumor immunity

Pyroptosis, an immunogenic programmed cell death, could efficiently activate tumor immunogenicity and reprogram immunosuppressive microenvironment for boosting cancer immunotherapy. However, the overexpression of SLC7A11 promotes glutathione biosynthesis for maintaining redox balance and countering pyroptosis. Herein, we develop intermetallics modified with glucose oxidase (GOx) and soybean phospholipid (SP) as pyroptosis promoters (Pd2Sn@GOx-SP), that not only induce pyroptosis by cascade biocatalysis for remodeling tumor microenvironment and facilitating tumor cell immunogenicity, but also trigger disulfidptosis mediated by cystine accumulation to further promote tumor pyroptosis in female mice. Experiments…

• HP
  Heilongjiang Postdoctoral Science Foundation

  Award: LBH-Z23014
• NN
  National Natural Science Foundation of China

  Awards: NSFC 52002091, U22A20316, U22A20347, 52002091
• CP
  China Postdoctoral Science Foundation

  Award: 2023TQ0091
• HI
  Harbin Institute of Technology
• NS
  Natural Science Foundation of Heilongjiang Province

  Award: LH2022H067
• EY
  Excellent Youth Foundation of Heilongjiang Province of China

  Award: YQ2023B005
• FR
  Fundamental Research Funds for the Central Universities

  Award: 3072023GIP1002