The multiple roles of interferon regulatory factor family in health and disease
Sichuan University · West China Hospital of Sichuan University · +4 more institutions
Abstract
Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly influence the immune system, impacting both physiological and pathological processes. This review explores the diverse functions of nine mammalian IRF members, each featuring conserved domains essential for interactions with other transcription factors and cofactors. These interactions allow IRFs to modulate a broad spectrum of physiological processes, encompassing host defense, immune response, and cell development. Conversely, their pivotal role in immune regulation implicates them in the pathophysiology of various diseases, such as infectious diseases, autoimmune disorders, metabolic diseases, and cancers. In this context,…
Citation impact
- FWCI
- 29.40
- Percentile
- 100%
- References
- 891
Authors
10- LWLian WangCorresponding
Sichuan University, West China Hospital of Sichuan University, State Key Laboratory of Biotherapy
- YZYanghui Zhu
Sichuan University, West China Hospital of Sichuan University
- NZNan Zhang
Chengdu University of Traditional Chinese Medicine
- YXYali Xian
Sichuan University, West China Hospital of Sichuan University
- YTYu Tang
Sichuan University, West China Hospital of Sichuan University
Topics & keywords
- Disease
- Interferon
- Interferon regulatory factors
- Immunology
- Medicine
- Computational biology
- Biology
- Pathology
- Good health and well-being