Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Iron, an essential mineral in the body, is involved in numerous physiological processes, making the maintenance of iron homeostasis crucial for overall health. Both iron overload and deficiency can cause various disorders and human diseases. Ferroptosis, a form of cell death dependent on iron, is characterized by the extensive peroxidation of lipids. Unlike other kinds of classical unprogrammed cell death, ferroptosis is primarily linked to disruptions in iron metabolism, lipid peroxidation, and antioxidant system imbalance. Ferroptosis is regulated through transcription, translation, and post-translational modifications, which affect cellular sensitivity to ferroptosis. Over the past decade or so, numerous…

• NN
  National Natural Science Foundation of China

  Awards: 82071970, 31930057, 32330047, 82072506, 31970689
• NS
  Natural Science Foundation of Hubei Province

  Award: 2024AFB971
• SF
  Science Fund for Distinguished Young Scholars of Hubei Province

  Award: 2023AFA109