Integrated multimodal cell atlas of Alzheimer’s disease
Allen Institute for Brain Science · University of Washington · +5 more institutions
Abstract
Abstract Alzheimer’s disease (AD) is the leading cause of dementia in older adults. Although AD progression is characterized by stereotyped accumulation of proteinopathies, the affected cellular populations remain understudied. Here we use multiomics, spatial genomics and reference atlases from the BRAIN Initiative to study middle temporal gyrus cell types in 84 donors with varying AD pathologies. This cohort includes 33 male donors and 51 female donors, with an average age at time of death of 88 years. We used quantitative neuropathology to place donors along a disease pseudoprogression score. Pseudoprogression analysis revealed two disease phases: an early phase with a slow increase in pathology, presence of…
Citation impact
- FWCI
- 51.25
- Percentile
- 100%
- References
- 119
Authors
108- MIMariano I. GabittoCorresponding
Allen Institute for Brain Science, University of Washington, Allen Institute
- KJKyle J. Travaglini
Allen Institute for Brain Science, Allen Institute
- VMVictoria M. Rachleff
Allen Institute for Brain Science, University of Washington, Allen Institute
- ESEitan S Kaplan
Allen Institute for Brain Science, Allen Institute
- BLBrian Long
Allen Institute for Brain Science, Allen Institute
Topics & keywords
- Neuropathology
- Neuroscience
- Microglia
- Neurodegeneration
- Remyelination
- Dementia
- Disease
- Alzheimer's disease
- Good health and well-being