Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy

The remarkable versatility of gold nanoparticles (AuNPs) makes them innovative agents across various fields, including drug delivery, biosensing, catalysis, bioimaging, and vaccine development. This paper provides a detailed review of the important role of AuNPs in drug delivery and therapeutics. We begin by exploring traditional drug delivery systems (DDS), highlighting the role of nanoparticles in revolutionizing drug delivery techniques. We then describe the unique and intriguing properties of AuNPs that make them exceptional for drug delivery. Their shapes, functionalization, drug-loading bonds, targeting mechanisms, release mechanisms, therapeutic effects, and cellular uptake methods are discussed, along…

• SH
  Sheikh Hamdan Bin Rashid Al Maktoum Award for Medical Sciences

  Award: MRG/18/2020
• SS
  Sheikh Saud bin Saqr Al Qasimi Foundation for Policy Research
• AU
  American University of Sharjah

  Awards: FRG20, AJF 2015555, FRG22-C-E08, FRG20-L-E48