Oxidative stress and inflammation in the pathogenesis of neurological disorders: Mechanisms and implications

Neuroprotection is a proactive approach to safeguarding the nervous system, including the brain, spinal cord, and peripheral nerves, by preventing or limiting damage to nerve cells and other components. It primarily defends the central nervous system against injury from acute and progressive neurodegenerative disorders. Oxidative stress, an imbalance between the body's natural defense mechanisms and the generation of reactive oxygen species, is crucial in developing neurological disorders. Due to its high metabolic rate and oxygen consumption, the brain is particularly vulnerable to oxidative stress. Excessive ROS damages the essential biomolecules, leading to cellular malfunction and neurodegeneration.…

• DO
  Department of Biotechnology, Ministry of Science and Technology, India
• UI
  Universitetet i Oslo
• NC
  National Centre for Cell Science
• KI
  Kalinga Institute of Industrial Technology
• MF
  Medisinske fakultet, Universitetet i Oslo