Charge-assisted stabilization of lipid nanoparticles enables inhaled mRNA delivery for mucosal vaccination
Chinese Academy of Sciences · Beijing National Laboratory for Molecular Sciences · +4 more institutions
Abstract
Inhaled delivery of messenger RNA (mRNA) using lipid nanoparticle (LNP) holds immense promise for treating pulmonary diseases or serving as a mucosal vaccine. However, the unsatisfactory delivery efficacy caused by the disintegration and aggregation of LNP during nebulization represents a major obstacle. To address this, we develop a charge-assisted stabilization (CAS) strategy aimed at inducing electrostatic repulsions among LNPs to enhance their colloidal stability. By optimizing the surface charges using a peptide-lipid conjugate, the leading CAS-LNP demonstrates exceptional stability during nebulization, resulting in efficient pulmonary mRNA delivery in mouse, dog, and pig. Inhaled CAS-LNP primarily…
Citation impact
- FWCI
- 23.97
- Percentile
- 100%
- References
- 55
Authors
16- SLShuai LiuCorresponding
Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, University of Chinese Academy of Sciences
- YWYixing Wen
Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, University of Chinese Academy of Sciences
- XSXinzhu Shan
Peking University
- XMXinghuan Ma
Dalian University of Technology, Dalian University
- CYChen Yang
Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, University of Chinese Academy of Sciences
Topics & keywords
- Charge (physics)
- Vaccination
- Nanoparticle
- Messenger RNA
- Chemistry
- Materials science
- Nanotechnology
- Medicine
- Zero hunger