Determining a Meaningful R-squared Value in Clinical Medicine

Introduction In clinical medicine, determining a meaningful R 2 value requires careful consideration of various factors. The R-squared (R 2 ) value is a statistical measure used to assess the extent to which independent variables explain the dependent variable in regression models. Its interpretation in clinical medicine is very context-dependent and lacks a definitive threshold. While a higher R 2 suggests a stronger relationship between variables, smaller R-squared values will still hold relevance, especially for multifactorial clinical outcomes. Due to clinical medicine’s genetic, environmental, and behavioral factors, high R 2 values may not be realistic or expected in this context. Methods This study is a…